New research indicates that individuals who come off blockbuster weight-loss injections like Wegovy and Mounjaro can put back on lost weight at a significantly accelerated pace than those who stop conventional diet and exercise plans.
Published data in a major medical journal shows that while obese people can lose a large proportion of their body weight while using the jabs, the weight returns at an estimated rate of nearly a kilo each month upon discontinuation.
"Users using these drugs must be aware of the risk of quick weight regain when the therapy ends," cautioned researcher Dr. Susan Jebb.
Such speed of recovery suggests a reversion to original mass within about a year and a half.
Analyzing Treatments
The research, which reviewed dozens of trials involving over 9,000 of patients, contrasted the effects of the injectable medications with other pills.
Researchers emphasize that individuals who shed pounds through lifestyle changes alone generally experience a less rapid weight regain—approximately 100 grams monthly—once they finish.
Explaining the Rapid Rebound
Experts propose the mechanism of the injections accounts for the heightened weight return.
The injections copy a body's own chemical called glucagon-like peptide-1, which helps regulate hunger.
"Artificially providing GLP-1 concentrations far above than normal may cause the system to produce less of its endogenous GLP-1, and may also diminish responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Stopping of this medication means appetite is unsuppressed, making binge eating a significant risk."
A Chronic Condition?
Health authorities advise the jabs for individuals with obesity-related medical conditions, accompanied by recommended lifestyle changes.
Professionals contend that, considering the likelihood of relapse, the therapy might need to be ongoing.
This opinion is reinforced by drug manufacturers, who say that the findings "underscore the long-term nature of excess weight," akin to managing diseases like hypertension.
Patient Accounts
Users who have discontinued the jabs describe a intense return of hunger.
"It felt as if a switch that goes on and you're instantly starving," recalled an individual.
This challenge is exacerbated if patients have not established permanent lifestyle or habit modifications during therapy.
Widespread Interest
Survey data suggest that millions of people in the UK have tried these injections in the past year, with desire continuing to grow.
- Use is higher among females than men.
- The 40s and 50s age group shows the highest level of interest.
- Many access the drugs through private prescriptions rather than the NHS.
Finally, clinicians caution that while GLP-1 drugs are powerful agents for weight loss, they are not a standalone cure and maintained weight loss hinges on integrated lifestyle management.
